Consultation
An initial consultation (1h30)
enables us to assess your health capital and determine your physiological age (your body's actual age) in relation to your chronological age (given by your date of birth). In the absence of symptoms or illness, our bodies age, starting in late adolescence (senescence).
The aim of this initial consultation is to assess the functional state of your physiological capacities
(cardiac, neurological, hormonal, vascular, osteoarticular).
A second consultation between 4 and 6 weeks (1h) enables us to summarize the data, assess your health capital and propose a personalized care plan to maintain and/or improve your functional capacities.
Comprehensive questionnaire
clinical examination
Anthropometric study
Anthropometric measurements :
the body mass index (BMI) or Quetelet index (1871) is the most widely used:
BMI= W/ H2 (W is weight in Kg and H is height in m²).
An individual is considered to be at a healthy weight if BMI is between 18.5 and 25kg/m2.
Waist circumference, measured at the height of the iliac crests, is a reliable indicator of an individual's cardio-metabolic risk. The critical threshold depends on BMI
For example, women with a healthy BMI should not have a waist circumference > 80 cm.
Impedancemetry
Bioimpedance is based on the relative resistance of a biological tissue to an electric current, and is used to calculate an individual's body composition.
The human body is made up of two types of compartments: the water compartment (intra- and extra-cellular water) and the tissue compartment, which includes fat mass (fatty tissue and triglycerides), lean mass (proteins + total water) and bone mass.
You can reduce your fat reserves by 50% without risk; on the other hand, if you halve your protein mass, mortality is increased by the reduction in your immune defences.
Fat mass remains an energy reserve. For women, less than 12% body fat increases the risk of chronic fatigue and menstrual cycle dysfunction,
bone mineralization disorders.
The water compartment represents between 47% and 57% of a woman's body weight. A distinction is made between two compartments: extracellular water, comprising plasma and the liquid in which cells are immersed (reserve), and intracellular water (functional water). These data provide information on the presence of edema or dehydration.
Balance of water intake and loss over a day for an adult.
CONTRIBUTIONS
Beverages: 1,200 ml
Food: 1,000 ml
Metabolism: 300 ml
LOSSES
Urine: 1250 ml
Skin: 800ml
Lungs: 350ml
Stool: 100ml
Calculation of the bone compartment by bioimpedance is 90% superimposable on bone mineral density calculated by Dual Energy X-ray Absorptiometry (DEXA).
biological tests
Metabolic balance
GLYCATION
The phenomenon of glycation, which occurs in all living organisms during aging, is a chemical reaction resulting from the binding of sugars to proteins, a kind of caramelization, leading to the loss of protein structure and functionality, particularly collagen and DNA.
This phenomenon is closely linked to glycemic balance.
With the explosion in consumption of products rich in added sugars, we're seeing a very high incidence of diabetes, responsible for accelerated ageing.
The telomeres at the ends of our chromosomes, known to control the longevity of our cells, are affected by glycation (shortening).
New studies suggest that glycation may have an impact on reproductive health in both men and women.
Assessing the degree of glycation at a given age is one of the levers on which we can act in longevity medicine.
OXIDATIVE STRESS
Oxidative stress is necessary for life, providing a signal that enables the body to activate defensive mechanisms such as inflammation and cell growth.
But when the stress is too great, it becomes toxic, with the production of free radicals that can lead to DNA oxidation with gene damage, lipid oxidation with damage to cell membranes and membrane receptors, and protein oxidation with damage to proteins and the enzyme system.
Excessive oxidative stress is responsible for accelerated aging.
Assessing the balance between oxidative stress and our anti-oxidant defenses is essential for preventive, personalized care.
VITAMIN BALANCE
Vitamin balance is essential to all our enzymatic reactions, and therefore to the maintenance of our homeostasis.
Before taking any vitamin A, C, E or B supplements, it is essential to assess vitamin status. Nutrition is the primary source of our vitamins.
As Hippocrates said, "Your food will be your first medicine".
Hormonal balance
In women, aging rhythms with menopause (loss of reproductive function and estrogen deficiency). Estrogen deficiency can aggravate a pre-existing risk, hence the importance of assessing risk factors* for cardiovascular disease, osteoporosis and neurodegenerative disease.
- Cumulative risk of osteoporotic fracture at age 50 = 40%.
- Cumulative 50-year risk of death from cardiovascular disease =45%.
- Cumulative risk of breast cancer = 1 woman/10
* Thyroid investigation, adrenal gland investigation (Cortisol, DHEA)
- Exploration of the thyroid gland:
the thyroid gland supports the reproductive, digestive, skeletal, cardiovascular and nervous systems; synthesis of thyroid hormones (T3 and T4) requires a good supply of Iodine and Thyrosine (an essential amino acid supplied by nutrition).
- Exploration of the adrenal glands: the Cortisol/DHEA balance controls our autonomic nervous system (sympathetic and parasympathetic), which is our adaptation system.
Neurotransmitter profile
Detection of dopamine deficiency (addiction, Parkinson's disease), serotonin deficiency (irritability, intolerance to frustration, snacking), noradrenaline deficiency (withdrawal), melatonin deficiency (problems falling asleep, waking up at night).
Fatty acid profile
Helps fine-tune nutritional balance.
Study of intestinal microbiota
Genetics
The development of a living organism is genetically programmed (genetic capital given by our ancestry). But exposure to environmental factors (tobacco, alcohol, endocrine disruptors, air pollution) from conception (intra-uterine life) to the end of life will impact gene expression. Genetic testing makes it possible to determine a genetic profile and assess predisposition to certain metabolic or endocrine dysfunctions, or to certain diseases.
Further tests
Arterial and venous Doppler, calcium score, neuro-visual assessment
Neurovisual assessment
Quantify cerebral disorders using gaze analysis and oculomotricity to improve patient care.